DXA-measured truncal adiposity in adolescence but not in childhood longitudinally predicts worsening cardiac outcomes
Authors' conclusion
Increased total and trunk fat mass from adolescence but not from childhood predicted progressive cardiac structural and functional pathologies by young adulthood.
Study context
- Population
- Children aged 9 years from the Avon Longitudinal Study of Parents and Children (ALSPAC) UK birth cohort with repeated DXA-measured fat mass at ages 9, 11, 15, 17 and 24 years; echocardiography at 17 and 24 years
- Participants
- 1,803 children
- Outcome
- LV mass indexed for height2.7 (LVM) by echocardiography
- Follow-up
- 17 and 24 years
Methodological detailslongitudinal, ALSPAC
- Longitudinal
- ALSPAC
Main finding
As reported in the abstract
Total fat mass increase, age 9-24 years: β (g/m2.7), 95% CI, P
−0.48
−0.50--0.48P < .001
Trunk fat mass increase, age 9-24 years: β (g/m2.7), CI, P
−0.78
−0.83 to −0.74P < .001
Total fat mass increase, age 17-24 years: β (g/m2.7), 95% CI, P
0.12
0.09–0.15P < .001
Trunk fat mass increase, age 17-24 years: β (g/m2.7), CI, P
0.23
0.18–0.28P < .001
Observational data: associations, not effects.
Further findings
Lean mass and BMI increase (age 9-24 years) and LVM
- Lean mass: β (g/m2.7), 95% CI, P
- 0.31 [0.29-0.33], P < .001
- BMI: β (g/m2.7), CI, P
- 0.24 [0.20-0.27], P < .001
Mediation of fat mass–cardiac mass association, adolescence to young adulthood
- Mediated by increased systolic BP
- 10.6%
- Mediated by high-sensitivity C-reactive protein
- 7.4%
- Partial mediation
Original publication
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