DXA ‐Derived Abdominal Adiposity and Obesity‐Related Cancer Risk Among Postmenopausal Women in the Women's Health Initiative
Authors' conclusion
Visceral adiposity has a strong, independent association with ObRC risk in postmenopausal women. Incorporating imaging-based body composition measures may improve cancer risk stratification and guide targeted prevention strategies.
Study context
- Population
- Postmenopausal women in the Women's Health Initiative (WHI) DXA cohort
- Participants
- 9,950 women177,295 person-years
- Exposure
- Abdominal VAT and SAT and ObRC incidence
- Outcome
- Incidence of 13 obesity-related cancers (ObRCs)
Methodological detailsFine and Gray competing-risks models, time-varying models
- Fine and Gray competing-risks models
- Time-varying models
Main finding
As reported in the abstract
ObRC risk by abdominal VAT
Each 100-cm² increase in VAT: higher risk
32%
Observational data: associations, not effects.
Further findings
SAT and VAT/SAT ratio
- SAT and VAT/SAT ratio also significantly associated with risk, more modestly
Subgroups and sensitivity analyses
- Consistent across BMI, waist circumference (WC), age and race/ethnicity strata and in time-varying models
Original publication
DXA ‐Derived Abdominal Adiposity and Obesity‐Related Cancer Risk Among Postmenopausal Women in the Women's Health Initiative. Obesity (Silver Spring). Published 20 March 2026. doi:10.
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