DXA-based bone strain index in normocalcemic primary hyperparathyroidism
Authors' conclusion
The trabecular and cortical bones assessed by BSI seem not to be significantly impaired in NHPT. Further prospective studies are needed to confirm these findings and to give an insight into the natural history of NHPT to improve knowledge and management of this condition.
Study context
- Population
- Subjects with normocalcemic hyperparathyroidism (NHPT), PHPT and matched controls
- Participants
- 170 subjects
- Comparison
- NHPT vs PHPT vs controls
- NHPTn = 40
- PHPTn = 50
- Controlsn = 80reference
- Outcome
- DXA-based bone strain index (BSI)
Methodological detailsage- and sex-matched controls
- Age- and sex-matched controls
Main finding
As reported in the abstract
BSI
- FN-BSI and TH-BSI: no differences between NHPT and controls
- LS-BSI not different between NHPT and both PHPT and controls
- NHPT vs PHPT: P = 0.031
- NHPT vs PHPT: P = 0.030
Observational data: associations, not effects.
Further findings
- Lumbar spine (LS) bone mineral density (BMD), femoral neck (FN) BMD, total hip (TH) BMD and TBS similar between NHPT and both PHPT and controls
Original publication
DXA-based bone strain index in normocalcemic primary hyperparathyroidism. Osteoporos Int. Published 14 January 2023. doi:10.
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