Does vertebral osteoporosis delay or accelerate lumbar disc degeneration? A systematic review
Authors' conclusion
Our systematic review shows that the majority of studies currently consider an association between vertebral osteoporosis and disc degeneration, but there is still a huge disagreement whether this association is positive or negative.
Study context
- Population
- Clinical, cadaveric and animal studies of vertebral osteoporosis and lumbar disc degeneration34 publications
- Outcome
- Relationship between vertebral osteoporosis and disc degeneration
Methodological detailsPRISMA
- PRISMA
Pooled result
As reported in the abstract
- Clinical studies: negative correlation
- 8
- Clinical studies: uncorrelated
- 4
- Cadaveric studies: negative correlation
- 1
- Cadaveric studies: not correlated
- 1
- Animal studies: positive correlation
- 5
- Animal studies: negative correlation
- 2
- Anti-osteoporosis drug intervention studies (all animal): positive association
- 5
- Anti-osteoporosis drug intervention studies (all animal): no correlation
- 1
Original publication
Does vertebral osteoporosis delay or accelerate lumbar disc degeneration? A systematic review. Osteoporos Int. Published 14 August 2023. doi:10.
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