Do Levothyroxine Adjustments During Pregnancy Differ Between Users of Tablet and Nontablet Formulation? A Real-World Study
Authors' conclusion
In pregnant women with non-post-thyroidectomy hypothyroidism lower LT4 dosages may be necessary to achieve TSH between 0.5 μIU/mL < TSH ≤ 2.5 μIU/mL with LT4 nontablet compared with tablet formulations (therapeutic superiority).
Study context
- Population
- Pregnant women with hypothyroidism on levothyroxine (LT4) (185 non-post-thyroidectomy, 27 post-thyroidectomy), university hospital, over 4 years
- Participants
- 212 women
- Exposure
- LT4 nontablet vs tablet formulation
- Nontabletn = 80
- Tabletn = 132reference
- Outcome
- LT4 dosage needed to achieve target TSH ≤2.5 μIU/mL
- Follow-up
- First half of pregnancy
Methodological detailssingle-centre, real-world
- Single-centre
- Real-world
Main finding
As reported in the abstract
Required LT4 dose for 90% probability of TSH ≤2.5 μIU/mL, non-post-thyroidectomy hypothyroidism
Observational data: associations, not effects.
Further findings
Predictors of achieving TSH target (adjusted multivariable probit model), non-post-thyroidectomy hypothyroidism
- LT4 dose an independent significant predictor
- P = 0.001
- Formulation an independent significant predictor
- P = 0.036
- Adjusted for maternal weight, thyroid volume and type of hypothyroidism
Original publication
Do Levothyroxine Adjustments During Pregnancy Differ Between Users of Tablet and Nontablet Formulation? A Real-World Study. Endocr Pract. Published 30 December 2025. doi:10.
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