Distinct plasma protein profiles after long-term remission of Cushing's disease
Authors' conclusion
Active CD is associated with profound alterations in plasma protein profiles across various functional domains. Long-term remission is accompanied by substantial, but incomplete normalization of plasma proteins.
Study context
- Population
- Patients with Cushing's disease (CD) sampled during active disease and long-term remission; controls with similar age and sex distribution26 CD, 80 controls
- Participants
- 26 / 26 / 80
- Exposure
- CD patients during active disease and long-term remission vs controls
- Active CDn = 26
- Remissionn = 26
- Controlsn = 80reference
- Outcome
- Plasma protein profiles (159 proteins by quantitative mass spectrometry) vs controls (false discovery rate-adjusted t-test)
- Follow-up
- Long-term remission (median 4.4 years, IQR 3.3-5.1)
Main finding
As reported in the abstract
Plasma proteins differing from controls
- Active CD: proteins differing from controls
- 78 out of 159
- Active CD: coagulation proteins differing from controls
- 11
- Active CD: transport proteins differing from controls
- 10
- Active CD: apolipoproteins differing from controls
- 3
- Proteins changed significantly after remission vs active disease
- 69
- Of the 78 initially altered proteins, similar to controls upon remission
- 56
- Remission: proteins remaining different from controls (incl. factor IX, factor XIII A chain, apolipoprotein A-II, several complement factors, extracellular matrix protein-1)
- 31
Observational data: associations, not effects.
Original publication
Distinct plasma protein profiles after long-term remission of Cushing's disease. J Clin Endocrinol Metab. Published 30 April 2026. doi:10.
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