Diabetes, Subclinical Myocardial Injury or Stress, and Risk of Heart Failure Subtypes: The Jackson Heart Study
Authors' conclusion
Both diabetes and subclinical myocardial damage significantly increase the risk of all HF types among Black individuals.
Study context
- Population
- Black adults in the Jackson Heart Study; mean age 54.6 years, 63.2% women, 22.3% with diabetes, 26.4% with subclinical myocardial injury, 9.4% with subclinical myocardial stress306 developed heart failure (HF)
- Participants
- 3,484 adults
- Exposure
- Diabetes and subclinical myocardial injury or stress vs neither
- Outcome
- Incident HF, HFpEF and HFrEF
- Follow-up
- Over 12 years
Methodological detailscommunity-based cohort (Jackson Heart Study)
- Community-based cohort (Jackson Heart Study)
Main finding
As reported in the abstract
HF, HFpEF and HFrEF
Each group vs no diabetes, no injury/stressHazard ratio (95% CI)
Diabetes + myocardial injuryHF
3.84(2.60–5.66)
Diabetes + myocardial injuryHFpEF
3.68(2.13–6.36)
Diabetes + myocardial injuryHFrEF
4.26(2.40–7.53)
Diabetes + myocardial stressHF
4.03(2.50–6.51)
Diabetes + myocardial stressHFpEF
5.71(3.11–10.47)
Diabetes + myocardial stressHFrEF
2.13(0.88–5.17)
- Incident HF
- 306 (151 HF with preserved ejection fraction (HFpEF) and 139 HF with reduced ejection fraction (HFrEF))
Observational data: associations, not effects.
Original publication
Diabetes, Subclinical Myocardial Injury or Stress, and Risk of Heart Failure Subtypes: The Jackson Heart Study. Diabetes Care. Published 6 January 2025. doi:10.
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