Data‐driven discovery of midlife cardiometabolic profile associated with incident early‐onset and late‐onset dementia
Authors' conclusion
Cardiometabolic patterns characterised by relatively high liver enzyme levels or systemic inflammation were associated with increased risks of early-onset and late-onset dementia. Identification of high-risk subgroups according to distinct cardiometabolic patterns might help develop more precise strategies for dementia prevention regardless of apolipoprotein E (APOE) ε4 status.
Study context
- Population
- UK Biobank participants; early-onset dementia analyses in those aged <65 years at baseline (n = 249,870), late-onset dementia analyses in those ≥65 at end of follow-up (n = 191,213)
- Participants
- 289,494 participants
- Exposure
- Cardiometabolic profile clusters vs relatively healthy pattern
- Outcome
- Incident early-onset and late-onset dementia
- Follow-up
- Median 14.1 years
Methodological detailsdata-driven cluster analysis of 12 cardiometabolic markers, UK Biobank
- Data-driven cluster analysis of 12 cardiometabolic markers
- UK Biobank
Main finding
As reported in the abstract
Each group vs cluster 5Hazard ratio (95% CI)
Cluster 3early-onset dementia
2.58(1.61–4.14)
Cluster 3late-onset dementia
1.36(1.09–1.71)
Cluster 4late-onset dementia
1.39(1.13–1.72)
- Early-onset dementia cases
- 279
- Late-onset dementia cases
- 3167
Observational data: associations, not effects.
Further findings
- No significant interactions between cardiometabolic clusters and apolipoprotein E (APOE) ε4 genotype
Original publication
Data‐driven discovery of midlife cardiometabolic profile associated with incident early‐onset and late‐onset dementia. Diabetes Obes Metab. Published 6 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →