Daily low dose aspirin halves incident type 2 diabetes in elderly subjects with prediabetes: a five-year longitudinal cohort study in a real-word population
Main finding · Incident T2DResult — go to the resultHazard ratio 0.53 95% CI 0.44–0.64Authors' conclusion
Daily treatment with 100 mg aspirin was associated with approximately a 50% reduction in the incidence of new-onset T2DM, but also with an increased risk of gastrointestinal bleeding, in elderly individuals with prediabetes.
Study context
- Population
- Elderly individuals with prediabetes in Naples, Italy, followed by primary care physicians, 2018–2022
- Exposure
- Daily low-dose aspirin vs no aspirin
- Outcome
- Onset of T2D: new diagnosis with antidiabetic prescriptions lasting >30 days
Methodological detailslongitudinal, propensity score matching, real-world primary care database
- Longitudinal
- Propensity score matching
- Real-world primary care database
Main finding
Incident T2D · follow-up period
Hazard ratio
0.53
95% CI 0.44–0.64
P < 0.001
Events by group
Aspirin
22.3 per 1000 person-years
174 events
Non-aspirin
40.2 per 1000 person-years
314 events
Aspirinvs Non-aspirin
HR 0.53 (95% CI 0.44–0.64); P < 0.001
As reported in the abstract
- New T2D cases overall
- 488 (15.6% of the total population)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Cumulative incidence of T2D (Kaplan-Meier)Lower with Aspirin | log-rank test p < 0.0001 |
Safety
Gastrointestinal bleeding · increased risk with Aspirin
P < 0.05
Original publication
Daily low dose aspirin halves incident type 2 diabetes in elderly subjects with prediabetes: a five-year longitudinal cohort study in a real-word population. Cardiovasc Diabetol. Published 18 June 2025. doi:10.
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