Continuous Ketone Monitoring in Diabetic Ketoacidosis: Prospective Multicenter Method-Comparison and Feasibility Study
Main finding · Agreement between CKM and venous BOHB (Bland-Altman)Result — go to the resultAverage difference −0.38 mmol/L 95% CI −1.63 to 0.88Authors' conclusion
CKM during DKA treatment was feasible, provided clinically accurate BOHB readings, and detected DKA resolution earlier than standard care.
Study context
- Population
- Adults (>18 years) in diabetic ketoacidosis (DKA) at two U.S. EDs; mean age 40.8 years, 56% male, 50% Black, 79% T1D, mean presenting BOHB 7.0 mmol/L (range 2.5–13.5)164 paired values analysed
- Participants
- 34 adults
- Exposure
- Interstitial BOHB by continuous ketone monitoring vs venous BOHB
- Outcome
- Level of agreement via Bland-Altman analysis between simultaneously collected CKM and venous BOHB values
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
Agreement between CKM and venous BOHB (Bland-Altman)
Average difference
−0.38 mmol/L
95% CI −1.63 to 0.88
CKMvs Venous BOHB
average difference −0.38 mmol/L (95% CI −1.63 to 0.88)
Observational data: associations, not effects.
Further findings
| Outcome | Mean difference (earlier detection) (min) (95% CI) | P value | |
|---|---|---|---|
| Time to detection of DKA resolutionCKMvs Standard careDetected 55 min earlier via CKM | 55 (26–84) | P = 0.001 | |
| −50050100Difference, min (linear scale) |
Correlation between continuous ketone monitoring (CKM) and venous BOHB
- Correlation (r)
- 0.96
- p
- P < 0.001
CKM value lower than venous
- Paired values with CKM lower than venous
- 79%
Safety
- Device-related complications
- 0
- CKM application and removal were well tolerated by all patients
Original publication
Continuous Ketone Monitoring in Diabetic Ketoacidosis: Prospective Multicenter Method-Comparison and Feasibility Study. Diabetes Technol Ther. Published 9 March 2026. doi:10.
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