Continuous Glucose Monitoring Identifies Youth with Prediabetes at Risk for Glycemic Progression
Authors' conclusion
CGM metrics outperformed HbA1c in predicting short-term glycemic progression in youth with prediabetes, supporting CGM as a promising adjunctive tool for early risk stratification.
Study context
- Population
- Youth aged 10–18 years with obesity and hemoglobin A1c (HbA1c) 5.7%-6.4% (prediabetes)
- Participants
- 29 participants
- Outcome
- Whether baseline CGM metrics identify those at highest risk for HbA1c progression
- Follow-up
- 6 months
Methodological details6-month follow-up, 14 days of continuous glucose monitoring (CGM) wear at baseline and follow-up; metrics derived with R iglu package
- 6-month follow-up
- 14 days of CGM wear at baseline and follow-up; metrics derived with R iglu package
Main finding
As reported in the abstract
Baseline CGM predictors of follow-up HbA1c and HbA1c change
- Time above 140 mg/dL was the strongest and only consistent independent predictor of higher follow-up HbA1c and worsening glycemic trajectory (PRESS-based multivariable models)
- Multiple baseline CGM metrics associated with follow-up HbA1c and HbA1c change in univariable analyses
- Adjusted for clinical covariates
Observational data: associations, not effects.
Further findings
Glycemic course over 6 months
- Regressed to normoglycemia
- 32%
- Progressed to HbA1c 6.5% (markedly elevated baseline CGM glycemic variability and hyperglycemia)
- 1 participant
- HbA1c and most CGM metrics remained stable
Original publication
Continuous Glucose Monitoring Identifies Youth with Prediabetes at Risk for Glycemic Progression. Diabetes Technol Ther. Published 23 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →