Composite Pheochromocytomas: More Common Than Expected and Associated With Distinct Clinical Profile
Authors' conclusion
Composite pheochromocytomas were associated with older age, lower computed tomography attenuation, distinct perioperative features, and a higher burden of hypertension. These findings suggest that this subgroup may require closer postoperative monitoring. Although Ki-67 was higher in composite pheochromocytomas, its prognostic significance remains uncertain.
Study context
- Population
- Patients with pheochromocytoma; 2 additional patients with mixed corticomedullary tumors analysed separately
- Participants
- 190 patients
- Exposure
- Composite vs typical pheochromocytoma
- Compositen = 28
- Typical pheochromocytoman = 160reference
- Outcome
- Clinical characteristics and outcomes
Main finding
As reported in the abstract
Composite vs Typical pheochromocytomaOdds ratio (95% CI)P value
Preoperative systolic hypertension; multivariable analysis
2.47(1.00–6.06)
P = 0.049Postoperative systolic BP elevation; multivariable analysis
3.24(1.30–8.11)
P = 0.012Postoperative diastolic BP elevation; multivariable analysis
4.66(1.79–12.11)
P = 0.002Observational data: associations, not effects.
Further findings
Age
P = 0.015
Unenhanced CT attenuation
P = 0.01
Laparoscopic adrenalectomy
P = 0.02
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Ki-67 expression in the 3% to 5% range | 28.68 (1.49–552.79) | P = 0.026 | |
| 0.050.21520Odds ratio (log scale) |
Unenhanced CT attenuation
- Composite less often detected as adrenal incidentalomas
Original publication
Composite Pheochromocytomas: More Common Than Expected and Associated With Distinct Clinical Profile. Endocr Pract. Published 12 May 2026. doi:10.
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