Comparison of Insulin Titration Strategies for Glycemic Control in Type 2 Diabetes: A Systematic Review and Network Meta-analysis
Authors' conclusion
Self-titration at least twice a week with health care provider support leads to superior HbA1c reduction in comparison with other strategies, without increasing the risk of severe hypoglycemia. This approach should be considered for clinical practice, where appropriate, to achieve optimal glycemic control in patients with type 2 diabetes.
Study context
- Population
- Patients with T2D in published trials of basal insulin titration strategies; PubMed, Embase, CENTRAL, CINAHL, EBSCO Open Dissertations searched to January 2024
- Comparison
- Basal insulin titration strategies compared with each other
- Outcome
- HbA1c reduction
Methodological detailsTheme, intensity, and provider/platform (TIP) framework categorization
- TIP framework categorization
Pooled result
As reported in the abstract
HbA1c
Mean difference (95% CI)
ST/High/S-HCPvs ST/High/S-App
−0.75(−1.26 to −0.25)
ST/High/S-HCPvs Conv/Low/HCP
−1.19(−1.67 to −0.72)
Safety
- Severe hypoglycemia risk did not differ significantly across strategies
Original publication
Comparison of Insulin Titration Strategies for Glycemic Control in Type 2 Diabetes: A Systematic Review and Network Meta-analysis. Diabetes Care. Published 24 April 2025. doi:10.
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