Clinical significance of prediabetes, undiagnosed diabetes and diagnosed diabetes on critical outcomes in COVID‐19: Integrative analysis from the Japan COVID ‐19 task force
Authors' conclusion
We documented the clinical characteristics and outcomes of Japanese COVID-19 patients according to HbA1c levels or diabetes co-morbidity. As well as undiagnosed and diagnosed diabetes, physicians should be aware of prediabetes related to COVID-19 severity.
Study context
- Population
- Hospitalized COVID-19 patients, >70 hospitals, Japan COVID-19 Task Force database, February 2020 to October 2021
- Participants
- 2,430 patients
- Exposure
- Prediabetes, undiagnosed diabetes mellitus (DM) and diagnosed DM vs no diabetes
- Outcome
- Critical outcomes: high-flow oxygen, invasive positive-pressure ventilation or extracorporeal membrane oxygenation, or death during hospitalization
- Follow-up
- During hospitalization
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Critical COVID-19 outcomes
Each group vs without diabetesAdjusted odds ratio (95% CI)
Prediabetes
2.13(1.31–3.48)
Undiagnosed diabetes
4.00(2.19–7.28)
Observational data: associations, not effects.
Further findings
| Outcome | Prediabetes | Undiagnosed diabetes | Diagnosed diabetes |
|---|---|---|---|
| Prevalence | 40.9% | 10.0% | 23.0% |
HbA1c and COVID-19 severity, within groups
- HbA1c associated with severity in prediabetes, aOR
- 11.2 (3.49-36.3) (95% CI)
- Not associated in other groups
Original publication
Clinical significance of prediabetes, undiagnosed diabetes and diagnosed diabetes on critical outcomes in COVID‐19: Integrative analysis from the Japan COVID ‐19 task force. Diabetes Obes Metab. Published 26 September 2022. doi:10.
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