Clinical and Demographic Characteristics Associated With Diabetes Remission in Six Integrated Health Care Systems: A Retrospective Cohort Study
Authors' conclusion
Type 2 diabetes remission was low among adults without bariatric surgery. The strongest associated characteristics were fewer diabetes medications, lower baseline HbA1c, and shorter diabetes duration. These findings highlight actionable factors to identify patients who may benefit most from targeted interventions. Future research should evaluate the long-term durability and health impacts of remission.
Study context
- Population
- Adults (≥18 years) with T2D, ≥1 HbA1c measurement in 2 years before entry and glucose-lowering medication use, 2014–2023; pregnant women and bariatric surgery excluded
- Participants
- 556,758 adults
- Exposure
- Characteristics associated with T2D remission
- Outcome
- T2D remission: HbA1c <6.5% persisting ≥3 months after cessation of glucose-lowering medications
- Follow-up
- 3-year follow-up
Methodological detailsmulticentre, electronic health record data, six US health care delivery systems, multivariate logistic regression
- Multicentre
- Electronic health record data, six US health care delivery systems
- Multivariate logistic regression
Main finding
As reported in the abstract
T2D remission (HbA1c <6.5% persisting ≥3 months after cessation of glucose-lowering medications)
OR for remission (95% CI)
No glucose-lowering medications at baselinevs ≥3 medications
15.9(12.1–21.0)
Baseline HbA1c <7%vs Baseline HbA1c ≥11%
3.1(2.9–3.3)
Diabetes duration <1 yearvs Diabetes duration ≥4 years
2.6(2.5–2.7)
- Achieved T2D remission
- 2.9% (16,016 adults)
- Relapsed among those with remission
- 36.9%
Observational data: associations, not effects.
Further findings
Relapse among those with remission · 3-year follow-up
- Relapsed
- 36.9%
Original publication
Clinical and Demographic Characteristics Associated With Diabetes Remission in Six Integrated Health Care Systems: A Retrospective Cohort Study. Diabetes Care. Published 30 July 2025. doi:10.
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