Circulating levels of peptide YY are increased in individuals with bile acid diarrhea
Authors' conclusion
Collectively, these results suggest a role for PYY as a marker for BAD pathophysiology
Study context
- Population
- Patients with bile acid diarrhoea (BAD) and healthy volunteers from earlier studies
- Comparison
- BAD vs matched healthy controls; colesevelam vs liraglutide; sequestrant cessation
- Primary endpoint
- Total plasma PYY
Methodological detailsrandomised controlled trial, sequestrant cessation study
- Randomised controlled trial
- Sequestrant cessation study
Primary result
As reported in the abstract
- Higher fasting plasma PYY in BAD vs controls
- Similar postprandial PYY increments in the two groups
Further findings
Fasting PYY with treatment
- Symptom-alleviating treatment of BAD with sequestrants or liraglutide resulted in a decline of fasting PYY
Correlates of fasting PYY
- Fasting PYY correlated positively with C4 and plasma total bile acids
PYY/GLP-1 ratio along the intestine
- PYY/GLP-1 ratio increased along the intestine, highest in the colon
Original publication
Circulating levels of peptide YY are increased in individuals with bile acid diarrhea. J Clin Endocrinol Metab. Published 24 July 2026. doi:10.
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