Changing presentation of acromegaly in half a century: a single-center experience
Authors' conclusion
There may be a trend for earlier detection of patients with acromegaly.
Study context
- Population
- Patients diagnosed with acromegaly between 1980 and 2023
- Participants
- 570 patients
- Exposure
- Patients diagnosed in the last decade vs those diagnosed before 2014
- Last decaden = 210
- Outcome
- Changes in characteristics of presentation of acromegaly over approximately half a century
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Presentation characteristics
- Diagnosed before 2014: longer symptom duration before diagnosis, older age, larger pituitary adenomas, more cavernous sinus invasion, higher GH and IGF-1 vs last decade
- Before 2014 vs Last decade: P < 0.05, for all
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Surgical remissionLower rate before 2014 | P < 0.001 |
| Comorbidities at diagnosis (DM, hypertension, colon polyps, thyroid cancer)Higher prevalence before 2014 | P < 0.05, for all |
Original publication
Changing presentation of acromegaly in half a century: a single-center experience. Pituitary. Published 31 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →