Changes in PTH Across the Spectrum of Renin-independent Aldosteronism
Authors' conclusion
Increasing PTH concentration and 24-hour urinary calcium excretion were observed across the spectrum of renin-independent aldosteronism. While PTH remained in the normal range for most patients, PA may be considered in patients with elevated PTH and normal serum calcium concentration.
Study context
- Population
- Adults screened for primary aldosteronism (PA) with a PTH measurement, Monash Health Endocrine Hypertension Clinic
- Participants
- 462 adults
- Exposure
- PTH across PA, low renin without PA and non-PA
- Outcome
- Serum PTH concentration
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Serum PTH
P < 0.05
Observational data: associations, not effects.
Further findings
24-h urinary calcium excretion — PA vs Non-PA
P < 0.05
- Elevated PTH with normal serum calcium, PA vs without PA · 38% vs 28%; more likely with PA
- P = 0.010
- 24-h urinary calcium excretion: increased progressively across the spectrum of renin suppression
Original publication
Changes in PTH Across the Spectrum of Renin-independent Aldosteronism. J Clin Endocrinol Metab. Published 7 March 2025. doi:10.
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