β-Cell Function and Insulin Sensitivity in Youth With Early Type 1 Diabetes From a 2-Hour 7-Sample Oral Glucose Tolerance Test (OGTT)
An erratum to this article was published (J Clin Endocrinol Metab, 14 Jul 2023 ↗)
Authors' conclusion
The 2-hour 7-point OGTT is reliable in individuals with stage 1 T1D for assessment of β-cell responsiveness, SI, and DI. Incorporation of these analyses into current 2-hour diabetes staging and monitoring OGTTs offers the potential to more accurately quantify risk of progression in the early stages of T1D.
Study context
- Population
- Lean youth with stage 1 T1D (≥ 2 islet autoantibodies with no dysglycemia)
- Participants
- 15 participants
- Comparison
- 2-hour 7-point and 5-point OGTT protocols vs 3-hour 9-point OGTT
- Primary endpoint
- Agreement of oral minimal model estimates of β-cell responsiveness (φtotal), SI and disposition index (DI = φtotal × SI) with the 3-hour 9-point OGTT
Methodological detailsvalidation study of OGTT sampling protocols
- Validation study of OGTT sampling protocols
Primary result
As reported in the abstract
Agreement of 2-h vs 3-h OGTT estimates of DI, β-cell responsiveness (φtotal) and SI
- Correlation of 2-hour with 3-hour estimates, DI
- r = 0.975; P < .001
- Correlation of 2-hour with 3-hour estimates, β-cell responsiveness
- r = 0.997; P < .001
- Correlation of 2-hour with 3-hour estimates, sensitivity (SI)
- r = 0.982; P < .001
- Agreement of 7-point 2-hour and 9-point 3-hour protocols within the 95% CI on the Bland-Altman grid; median difference, DI
- 16.9% (−35.3 to 32.5)
- Agreement of 7-point 2-hour and 9-point 3-hour protocols within the 95% CI on the Bland-Altman grid; median difference, φtotal
- 0.2% (−0.6 to 1.3)
- Agreement of 7-point 2-hour and 9-point 3-hour protocols within the 95% CI on the Bland-Altman grid; median difference, SI
- 14.9% (−1.4 to 28.3)
Further findings
5-point 2-hour protocol: φ dynamic and static components
- 5-point protocol did not provide reliable estimates of φ dynamic and static components
Original publication
β-Cell Function and Insulin Sensitivity in Youth With Early Type 1 Diabetes From a 2-Hour 7-Sample OGTT. J Clin Endocrinol Metab. Published 21 December 2022. doi:10.
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