Case Series of 46 Patients With Nonketotic Hyperglycemia-associated Chorea: A Retrospective Follow-up Study
Authors' conclusion
To our knowledge, this study represents the largest case series of NKHC to date, offering valuable insights into the clinical and imaging characteristics of this condition.
Study context
- Population
- Patients with acute-onset hemichorea/hemiballismus, nonketotic hyperglycemia (random blood glucose ≥11.1 mmol/L) and basal ganglia abnormalities on magnetic resonance imaging (MRI), 2013–2022
- Participants
- 46 patients
- Outcome
- Clinical and imaging characteristics
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
- Age
- mean 68.6 ± 10.4 years (range 48-89)
- HbA1c
- mean 11.4% ± 3.8%
- T1-weighted hyperintensity in contralateral basal ganglia on MRI
- 91.3%
- Normoglycemia at admission with typical chorea
- 26.1%
- Symptom exacerbation despite T1 signal resolution on follow-up MRI
- 2 cases
Observational data: associations, not effects.
Original publication
Case Series of 46 Patients With Nonketotic Hyperglycemia-associated Chorea: A Retrospective Follow-up Study. J Clin Endocrinol Metab. Published 19 July 2025. doi:10.
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