Cardiovascular outcomes of patients with type 2 diabetes after myocardial infarction and the impact of diabetes duration: a nationwide registry study
Main finding · Cumulative incidence of MACEResult — go to the resultSubdistribution hazard ratio 1.36 95 % CI 1.31–1.41Authors' conclusion
Patients with type 2 diabetes have impaired long-term cardiovascular outcomes after an MI, underlining the importance of effective secondary prevention. Patients with a longer diabetes duration are at a particularly high risk.
Study context
- Population
- Patients surviving 90 days after myocardial infarction (MI) during 2004–2018, Finnish nationwide registries10,300 matched pairs
- Participants
- 10,440 vs 65,315
- Exposure
- T2D vs no diabetes after MI
- Type 2 diabetesn = 10,440
- Without diabetesn = 65,315reference
- Outcome
- MACE: recurrent MI, ischemic stroke, HF hospitalization or cardiovascular death
- Follow-up
- Median (maximum) 3.7 (12) years
Methodological detailscompeting risk Fine-Gray analyses, multivariable adjustment, propensity score matching
- Competing risk Fine-Gray analyses
- Multivariable adjustment
- Propensity score matching
Main finding
Cumulative incidence of MACE · 12 years
Subdistribution hazard ratio
1.36
95 % CI 1.31–1.41
By group
Type 2 diabetesvs Without diabetes
sHR 1.36 (95 % CI 1.31–1.41)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | sHR (95 % CI) | |
|---|---|---|
| Recurrent MI | 1.49 (1.41–1.57) | |
| Ischemic stroke | 1.14 (1.05–1.23) | |
| HF hospitalization | 1.48 (1.40–1.57) | |
| Cardiovascular death | 1.30 (1.24–1.36) | |
| 0.512Subdistribution hazard ratio (log scale) |
Diabetes duration
- Longer diabetes duration was associated with major adverse cardiovascular event (MACE), recurrent MI, HF and cardiovascular death
Original publication
Cardiovascular outcomes of patients with type 2 diabetes after myocardial infarction and the impact of diabetes duration: a nationwide registry study. Diabetes Res Clin Pract. Published 7 August 2025. doi:10.
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