Cardiometabolic Gains Unrelated to Weight Loss–Adjusted Body Fat or Distribution Changes in Adults With and Without Diabetes
Authors' conclusion
Cardiometabolic improvements from weight loss appear independent of changes in body fat percentage or fat distribution.
Study context
- Population
- Adults with obesity and T2D (Study I) and adults with overweight/obesity without diabetes (Study II)
- Comparison
- Weight loss-adjusted changes in body fat % or fat distribution vs cardiometabolic changes
- Primary endpoint
- Association of weight loss-adjusted changes in body composition or fat distribution with cardiometabolic improvements
Methodological detailsregression adjustment for baseline values and weight loss
- Regression adjustment for baseline values and weight loss
Primary result
As reported in the abstract
Association of weight loss-adjusted body fat % or fat distribution changes with cardiometabolic changes
- No cardiometabolic changes were associated with weight loss-adjusted changes in body fat percentage or fat distribution
Further findings
Body weight decrease; fat mass share of weight lost
Fat mass share of weight lost Study I 64% (95% CI: 0.51%-0.77%) · Study II 77% (95% CI: 0.68%-0.86%)
Insulin sensitivity
- Clamp-derived insulin sensitivity increase (Study I)
- 50%
- HOMA-IR decrease in both studies
- 26%
Original publication
Cardiometabolic Gains Unrelated to Weight Loss–Adjusted Body Fat or Distribution Changes in Adults With and Without Diabetes. Obesity (Silver Spring). Published 25 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →