C-type natriuretic peptide and collagen X marker are aberrant in skeletal dysplasias
Authors' conclusion
Although limited numbers of affected individuals within each group were studied employing a single sample at one time point, the results indicate aberrant responses both within biomarkers and when related to HV.
Study context
- Population
- Children with skeletal dysplasias, comprising 7 distinct forms7 forms of SD
- Participants
- 73 children
- Outcome
- Association of plasma bioactive CNP, bio-inactive NTproCNP and collagen X marker (CXM) with age and with annualized height velocity
Methodological detailsSingle sample at one time point; limited numbers per disorder
- Single sample at one time point; limited numbers per disorder
Main finding
As reported in the abstract
Association of CNP, NTproCNP and CXM with age and height velocity
- Significant associations with age in several disorders
- Association of NTproCNP and collagen X marker (CXM) with height velocity aberrant except in type II collagen disorders and MOPD II
- In OI, CNP and NTproCNP reduced in proportion to severity of OI phenotype; reduction in CNP exceeded NTproCNP
- In OI, biomarkers dissociated and unrelated to height velocity across a wide range of height velocity
- Similar changes in multiple epiphyseal dysplasia, microcephalic osteodysplastic primordial dwarfism type II and Morquio A syndrome
Observational data: associations, not effects.
Original publication
C-type natriuretic peptide and collagen X marker are aberrant in skeletal dysplasias. J Bone Miner Res. Published 23 June 2025. doi:10.
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