C‐peptide index at 2 h post‐meal is a useful predictor of endogenous insulin secretory capacity and withdrawal from insulin therapy in subjects with type 2 diabetes
Authors' conclusion
The CPI at 2 h post-meal is a clinically useful measure of endogenous insulin secretory capacity under non-fasting conditions.
Study context
- Population
- Hospitalised patients with T2D on insulin therapy, single centre
- Participants
- 72 vs 75
- Exposure
- Withdrawal vs non-withdrawal from insulin therapy at discharge
- Withdrawaln = 72
- Non-withdrawaln = 75reference
- Outcome
- C-peptide index (CPI) at 2 h post-meal
- Follow-up
- 2 h post-meal
Methodological detailssingle-centre, machine learning prediction models
- Single-centre
- Machine learning prediction models
Main finding
As reported in the abstract
Withdrawal
2.97
± 2.07
Non-withdrawal
1.93
± 1.28
P < 0.001
Observational data: associations, not effects.
Further findings
HbA1c of study participants
- HbA1c (mmol/mo)
- 87.8 ± 22.6
Accuracy of 2 machine-learning clinical models (age, diabetes duration, creatinine, ALT, insulin therapy until hospitalisation, C-peptide index (CPI) at 2 h post-meal) predicting insulin withdrawal
- Accuracy range
- 78.3% to 82.6%
Original publication
C‐peptide index at 2 h post‐meal is a useful predictor of endogenous insulin secretory capacity and withdrawal from insulin therapy in subjects with type 2 diabetes. Diabetes Obes Metab. Published 22 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →