Birth weight, childhood body mass index, and risk of diverticular disease in adulthood
Authors' conclusion
BMI z-scores below and above zero in childhood were associated with higher risk of DD before age 50. In addition, we observed lower risk of DD among women, the higher their birthweight.
Study context
- Population
- Persons born 1930–1996 with records in the Copenhagen School Health Records Register; birthweight and height and weight from ages 7 through 13; Diverticular disease (DD) from the Danish National Patient Registry
- Participants
- 346,586 persons
- Exposure
- Birthweight and childhood body mass index (BMI) z-scores in relation to diverticular disease
- Outcome
- Diverticular disease (DD) registered in the Danish National Patient Registry
- Follow-up
- From age 18-49 and from age 50
Methodological detailsCopenhagen School Health Records Register, Cox proportional hazard regression
- Copenhagen School Health Records Register
- Cox proportional hazard regression
Main finding
As reported in the abstract
DD before age 50 by BMI z-score at age 13 · age 18-49
Women, z-scores <0 at age 13: HR per one-point lower z-score
1.16
95% CI 0.98–1.39
Women, z-scores ≥0 at age 13: HR per one-point higher z-score
1.30
95% CI 1.11–1.51
Men, z-scores <0 at age 13: HR
1.02
95% CI 0.85–1.22
Men, z-scores ≥0 at age 13: HR
1.54
95% CI 1.34–1.78
Observational data: associations, not effects.
Further findings
DD incidence during follow-up
- Women with DD
- 5459 (3.2%)
- Men with DD
- 4429 (2.5%)
DD after age 50 by BMI z-score ≥0
- Z-scores ≥0 were not associated with DD after age 50
Birthweight and DD before age 50, women only · age 18-49
- HR per 500 g higher birthweight (inverse association, women only)
- 0.90 (95% CI: 0.83-0.99)
Original publication
Birth weight, childhood body mass index, and risk of diverticular disease in adulthood. Int J Obes (Lond). Published 25 January 2023. doi:10.
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