Baseline and 4‐year associations between prediabetes and kidney impairment: Insights from the ILERVAS cohort
Main finding · Kidney impairment prevalenceResult — go to the resultOdds ratio 1.17 95% CI 1.03–1.34Authors' conclusion
HbA1c-defined prediabetes is independently associated with early renal impairment and accelerated kidney function decline. These findings support incorporating renal risk assessment in prediabetes and suggest HbA1c as a marker for chronic kidney disease prevention strategies.
Study context
- Population
- Individuals with no diagnosis of diabetes or established CVD, ILERVAS cohort3,222 reassessed at 4 years
- Participants
- 8,153 individuals
- Exposure
- Prediabetes vs no prediabetes
- Outcome
- Kidney impairment: eGFR <60 mL/min/1.73 m² and/or urinary albumin-to-creatinine ratio (ACR) ≥30 mg/g at a single time point
- Follow-up
- Baseline
Methodological detailsmultivariable regression adjusted for confounders
- Multivariable regression adjusted for confounders
Main finding
Kidney impairment prevalence
Odds ratio
1.17
95% CI 1.03–1.34
P = 0.020
By group
Prediabetesvs No prediabetes
OR 1.17 (95% CI 1.03–1.34); P = 0.020
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | β (95% CI) | P value |
|---|---|---|
| eGFR (adjusted association with prediabetes) · baselineLower eGFR · multivariable regression adjusted for confounders | −0.76 (−1.40 to −0.13) | P = 0.019 |
eGFR per 1% increase in haemoglobin A1c (HbA1c) · baseline
- Decrease in eGFR per 1% increase in HbA1c
- 4.6 mL/min/1.73 m²
eGFR decline at 4-year follow-up
- Prediabetes predicted further eGFR decline; HbA1c increase independently associated with eGFR decline
Original publication
Baseline and 4‐year associations between prediabetes and kidney impairment: Insights from the ILERVAS cohort. Diabetes Obes Metab. Published 18 February 2026. doi:10.
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