Associations of age at T2D detection with hemoglobin A1c in a national inception cohort of U.S. Veterans with diabetes
Authors' conclusion
Among male Veterans, early-onset T2D was associated with greater HbA1c and greater HbA1c variability. Similar results were seen among women but of lesser magnitude. Longitudinal research examining sex-specific impacts of early-onset T2D on clinical course is needed.
Study context
- Population
- U.S. Veterans with incident T2D (1/1/2008–12/31/2016)
- Participants
- 851,302 veterans
- Exposure
- Early-onset T2D vs later-onset T2D
- Outcome
- HbA1c (after detection, mean HbA1c, HbA1c CV)
Methodological detailsnational
- National
Main finding
As reported in the abstract
HbA1c in men: early-onset vs later-onset T2D
Each group vs later-onset T2DEstimate (95 % CI)
Early-onset T2D
difference in HbA1c after detection 0.71(0.69,0.73)
Early-onset T2D
difference in mean HbA1c 0.78(0.77,0.80)
Early-onset T2D
difference in HbA1c CV 0.05(0.04,0.05)
- Early-onset T2D in men
- About 3 % (n = 22,649)
Observational data: associations, not effects.
Further findings
| Outcome | Difference in HbA1c CV (95 % CI) | |
|---|---|---|
| Women: early-onset vs later-onset T2DEarly-onset T2Dvs Later-onset T2DWomen; greater with early-onset | 0.01 (0.01,0.01) | |
| −0.00500.0050.010.015Difference (linear scale) |
| Outcome | Difference in HbA1c after detection (95 % CI) |
|---|---|
| Women: early-onset vs later-onset T2DEarly-onset T2D vs Later-onset T2D · women; lower with early-onset | 0.14 (−0.18,−0.10) |
- Women: early-onset vs later-onset T2D — Early-onset T2D in women
- 11 % (n = 5,117)
Men: per 10-year decrease in age at detection
- HbA1c after detection, β
- 0.21 (0.21,0.21) (95 %CI)
- Mean HbA1c, β
- 0.25 (0.24,0.25) (95 %CI)
- HbA1c coefficient of variation (CV), β
- 0.02 (0.02,0.02) (95 %CI)
Women: per 10-year decrease in age at detection
- Mean HbA1c, β
- 0.09 (0.08,0.10) (95 %CI)
- HbA1c CV, β
- 0.01 (0.01,0.01) (95 %CI)
Original publication
Associations of age at T2D detection with hemoglobin A1c in a national inception cohort of U.S. Veterans with diabetes. Diabetes Res Clin Pract. Published 20 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →