Associations of Adiposity With Cortical Atrophy and Network Dyssynchrony in Type 2 Diabetes: A Multimodal MRI Study
Authors' conclusion
Adiposity is profoundly associated with structural and functional neural disruption in T2DM. Comorbid obesity represents a prominent risk factor associated with brain morphometric patterns resembling advanced aging
Study context
- Population
- Matched participants with T2D (obese or normal weight) and healthy controls undergoing high-resolution multimodal MRImatched
- Participants
- 102 participants
- Exposure
- Obese T2D vs normal-weight T2D vs healthy controls
- Obese T2DMn = 31
- Normal-weight T2DMn = 40
- Healthy controlsn = 31reference
- Outcome
- Cortical thickness, area and network synchronization
Methodological detailsmatched, multimodal MRI (Surface-Based Morphometry (SBM) and 2D-ReHo)
- Matched
- Multimodal MRI (SBM and 2D-ReHo)
Main finding
As reported in the abstract
- Obese T2D showed profound structural and functional vulnerability vs normal-weight peers
- High body mass index (BMI) robustly predicted severe cortical thinning in frontal-reward circuits and widespread functional dyssynchrony within the default mode network
- Localized morphometric increases in the fusiform gyrus unique to obese T2D (SBM)
- Disease duration showed no significant correlation with these metrics
Observational data: associations, not effects.
Original publication
Associations of Adiposity With Cortical Atrophy and Network Dyssynchrony in Type 2 Diabetes: A Multimodal MRI Study. Diabetes Obes Metab. Published 9 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →