Associations of cumulative exposure and dynamic trajectories of the C-reactive protein-triglyceride-glucose index with incident stroke in middle-aged and older Chinese adults: a longitudinal analysis based on China Health and Retirement Longitudinal Study (CHARLS)
An erratum to this article was published (Cardiovasc Diabetol, 20 Aug 2026 ↗)
Main finding · StrokeResult — go to the resultHazard ratio 1.90 95% CI 1.30–2.78Authors' conclusion
This study demonstrates that both cuCTI and CTI changes are associated with stroke risk in middle-aged and older adults, particularly for those with consistently high CTI levels, which are linked to a significantly increased stroke risk. Monitoring long-term CTI changes and maintaining relatively low levels may help prevent stroke in this population.
Study context
- Population
- Middle-aged and older Chinese adults, China Health and Retirement Longitudinal Study (CHARLS)
- Participants
- 4,364 participants
- Exposure
- Cumulative CTI quartiles and CTI change trajectories
- Outcome
- Self-reported stroke
Methodological detailslongitudinal, CHARLS
- Longitudinal
- CHARLS
Main finding
Stroke
Hazard ratio
1.90
95% CI 1.30–2.78
P < 0.001
Q4vs Q1
HR 1.90 (95% CI 1.30–2.78); P < 0.001
As reported in the abstract
- Stroke events
- 323 (7.4%)
Observational data: associations, not effects.
Further findings
Stroke by CTI trajectory (K-means, three trajectories)
- Moderate and elevated CTI levels: HR (95% CI 1.17-2.00), P = 0.001
- 1.53
- High CTI levels with slow increasing trend: HR (95% CI 1.25-2.48), P < 0.001
- 1.75
Original publication
Associations of cumulative exposure and dynamic trajectories of the C-reactive protein-triglyceride-glucose index with incident stroke in middle-aged and older Chinese adults: a longitudinal analysis based on CHARLS. Cardiovasc Diabetol. Published 6 October 2025. doi:10.
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