Associations between muscle mass and strength and bone microarchitecture in Caucasian postmenopausal women
Authors' conclusion
In summary, greater ALMI and hand grip strength are associated with increased cortical area and trabecular vBMD, but lower cortical vBMD, which is partially explained by physical activity levels. Although greater muscle mass is correlated with larger bones, it comes at the expense of cortical vBMD in postmenopausal women.
Study context
- Population
- Caucasian postmenopausal women, mean ± SD age 55.9 ± 2.6 years, OsteoPreP Study baseline
- Participants
- 160 women
- Outcome
- Associations of muscle mass (ALMI) and hand grip strength with high-resolution peripheral quantitative computed tomography (HR-pQCT) bone microarchitecture (cortical and trabecular vBMD, trabecular thickness, cortical area, porosity) at distal tibia and radius
Methodological detailsbaseline examination of the OsteoPreP Study, linear regression adjusted for confounders
- Baseline examination of the OsteoPreP Study
- Linear regression adjusted for confounders
Main finding
As reported in the abstract
Cortical area per 1 kg/m² appendicular lean mass index (ALMI) increase
2.55 mm²
p < 0.001
Trabecular volumetric bone mineral density (vBMD) per 1 kg/m² ALMI
9.44 mg/cm³
p = 0.013
Cortical vBMD per 1 kg/m² ALMI (lower)
- 11.37 mg/cm³
p = 0.039
Cortical area per 1 kg hand grip strength
0.67 mm²
p = 0.001
Observational data: associations, not effects.
Further findings
Mediation of ALMI–cortical vBMD association by physical activity (MET-hours/week)
- Partial mediation by physical activity
- - 2.01 mg/cm³, 95% CI: - 5.25 to - 0.03
Original publication
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