Associations between diabetic neuropathy and bone density and bone microarchitecture in type 2 diabetes: The Deep Phenotyping Study
Main finding · Areal bone mineral density at the total hip, individuals < 65 yearsResult — go to the resultβ −0.15 g/cm² 95% CI −0.24 to-0.06Authors' conclusion
In individuals with type 2 diabetes <65 years, diabetic neuropathy is associated with lower bone density and differences in cortical and trabecular microarchitecture. These findings suggest neuropathy may be associated with impaired bone quality in younger adults with type 2 diabetes.
Study context
- Population
- Individuals with type 2 diabetes with and without diabetic neuropathy, stratified by age
- Participants
- 50 vs 73
- Exposure
- Individuals with type 2 diabetes with vs without diabetic neuropathy
- WITH NEUROPATHYn = 50
- WITHOUT NEUROPATHYn = 73
- Outcome
- Areal bone mineral density at the total hip, individuals < 65 years
Methodological detailsmultivariable linear regression adjusted for age, sex, and BMI, age-stratified analyses ( < 65 and ≥65 years)
- Multivariable linear regression adjusted for age, sex, and BMI
- Age-stratified analyses ( < 65 and ≥65 years)
Main finding
As reported in the abstract
β
−0.15 g/cm²
95% CI −0.24 to-0.06
Observational data: associations, not effects.
Further findings
| Outcome | Estimate |
|---|---|
| Areal bone mineral density at the femoral neck, individuals < 65 yearsLower with neuropathy · adjusted for age, sex, and BMI | β −0.18 g/cm² (CI −0.26 to −0.09) |
| TBS, individuals < 65 yearsLower with neuropathy · adjusted for age, sex, and BMI | β −1.56 (CI −2.23 to −0.89) |
Tibia microarchitecture, individuals < 65 years
- Neuropathy was associated with lower total, cortical and trabecular volumetric bone mineral density, lower trabecular bone volume fraction, and higher cortical porosity
Radius microarchitecture, individuals < 65 years
- Lower cortical volumetric bone mineral density and lower trabecular number were observed
Bone Material Strength index; individuals ≥ 65 years
- No significant associations were observed for Bone Material Strength index or in individuals ≥ 65 years
Original publication
Associations between diabetic neuropathy and bone density and bone microarchitecture in type 2 diabetes: The Deep Phenotyping Study. Osteoporos Int. Published 14 November 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →