Associations Between Adiponectin and the Development of Diabetes in Rheumatoid Arthritis
Main finding · Incident diabetesResult — go to the resultHazard ratio 1.70 CI 1.34–2.16Authors' conclusion
The relationship between adiponectin and incident diabetes risk is U-shaped in RA. Patients with very high adiponectin levels have greater systemic inflammation and an altered relationship between adiponectin and diabetes risk.
Study context
- Population
- Adults with Rheumatoid Arthritis (RA) from the Veterans Affairs Rheumatoid Arthritis Registry1,689 without prevalent diabetes
- Participants
- 2,595 adults
- Exposure
- Adiponectin categories
- >40 μg/mLn = 379
- Outcome
- Incident diabetes
Methodological detailsmultivariable Cox proportional hazard models
- Multivariable Cox proportional hazard models
Main finding
As reported in the abstract
Hazard ratio
1.70
CI 1.34–2.16
P < 0.001
>40 μg/mLvs 10-40 μg/mL
HR 1.70 (CI 1.34–2.16); P < 0.001
- New cases of diabetes among 1689 patients without prevalent disease
- 125
Observational data: associations, not effects.
Further findings
Inflammatory cytokines and effect modification
- Adiponectin >40 μg/mL: significantly higher inflammatory cytokines, with evidence of modified effect of adiponectin on diabetes risk in inflammation
- Adiponectin >40 μg/mL: older and lower body mass index (BMI)
Original publication
Associations Between Adiponectin and the Development of Diabetes in Rheumatoid Arthritis. J Clin Endocrinol Metab. Published 8 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →