Association of the triglyceride-glucose index combined with a body shape index with all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome stage 0–3: findings from two prospective cohorts
Authors' conclusion
Among individuals with CKM stages 0-3, TyG-ABSI demonstrates a stronger association with mortality risk and superior predictive ability compared with other TyG-derived metrics. Its performance suggests a potential role in capturing variations across diverse clinical subgroups, and informing optimal timing for preventive interventions.
Study context
- Population
- Individuals with cardiovascular-kidney-metabolic syndrome (CKM) stages 0–3, NHANES cohort (1999–2018); external validation in CHARLSNHANES cohort
- Participants
- 13,480 individuals
- Exposure
- Higher vs lower TyG-ABSI
- Outcome
- All-cause mortality and CVD mortality
Methodological detailstwo prospective cohorts, external validation in CHARLS, Cox proportional hazards models and restricted cubic spline functions
- Two prospective cohorts
- External validation in CHARLS
- Cox proportional hazards models and restricted cubic spline functions
Main finding
As reported in the abstract
All-cause mortality, HR
1.226
95% CI 1.104–1.361
Cardiovascular mortality, HR
1.377
95% CI 1.149–1.651
Observational data: associations, not effects.
Further findings
Prognostic performance of TyG-ABSI (time-dependent ROC) · 5-15 years
- AUC, all-cause mortality
- 0.688-0.708
- AUC, cardiovascular mortality
- 0.696-0.739
- More accurate long-term prognostic performance than other triglyceride-glucose (TyG)-derived metrics
External validation (CHARLS)
- Confirmed robustness of findings in predicting all-cause mortality
Original publication
Association of the triglyceride-glucose index combined with a body shape index with all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome stage 0–3: findings from two prospective cohorts. Cardiovasc Diabetol. Published 23 September 2025. doi:10.
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