Association of Maternal Short Sleep Duration With Neurodevelopmental Delay in Offspring: A Prospective Cohort Study
Authors' conclusion
Maternal SSD during pregnancy was continuously associated with an increased incidence of neurodevelopmental delay with sex differences among offspring. This association may be mediated in part by increased higher levels of cord C-peptide.
Study context
- Population
- Mother-child pairs from the Maternal & Infants Health in Hefei cohort; 3 hospitals and children's health centers in Hefei
- Participants
- 7,059 mother-child pairs
- Exposure
- Maternal short sleep duration (SSD) during pregnancy vs no SSD
- Outcome
- Offspring neurodevelopmental delay (Denver Developmental Screening Test-II and Gesell Development Diagnosis Scale)
- Follow-up
- 6 to 36 months postpartum
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Neurodevelopmental delay in boys, maternal SSD during midpregnancy
Adjusted HR
2.05
95% CI 1.29, 3.25
Observational data: associations, not effects.
Further findings
Cord blood serum C-peptide and offspring neurodevelopmental delay
- RR
- 0.04 (95% CI 0.00, 0.08)
- Proportion of SSD–delay association mediated by cord blood C-peptide
- 11.05%
- Mediation analysis
Original publication
Association of Maternal Short Sleep Duration With Neurodevelopmental Delay in Offspring: A Prospective Cohort Study. J Clin Endocrinol Metab. Published 26 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →