Association of Estimated Glomerular Filtration Rate With Progression of Albuminuria in Individuals With Type 2 Diabetes
Authors' conclusion
This study of Japanese adults with type 2 diabetes suggests that both high and low GFRs are implicated in the pathogenesis of albuminuria progression.
Study context
- Population
- Japanese adults with T2D and urinary albumin-to-creatinine ratio <300 mg/g; 2,459 women and 4,159 men, mean (± SD) age 60 ± 12 years1,190 reached outcome
- Participants
- 6,618 adults
- Exposure
- Baseline estimated GFR (eGFR) categories vs 75-90 mL/min/1.73 m²
- Outcome
- Progression of albuminuria category (normo- to micro- or macroalbuminuria, or micro- to macroalbuminuria)
- Follow-up
- Median 6.3 years
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
Progression of albuminuria category
Each group vs eGFR 75-90Hazard ratio (95% CI)
eGFR ≥90
1.38(1.14–1.66)
eGFR 60-75
1.34(1.14–1.58)
eGFR 45-60
1.81(1.50–2.20)
eGFR <45
2.37(1.84–3.05)
Observational data: associations, not effects.
Further findings
Baseline eGFR as continuous variable (multivariable-adjusted restricted cubic spline)
- Inverse J-shaped curve more clearly shown by the spline model
Original publication
Association of Estimated Glomerular Filtration Rate With Progression of Albuminuria in Individuals With Type 2 Diabetes. Diabetes Care. Published 18 November 2022. doi:10.
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