Association of different insulin resistance surrogates with all-cause and cardiovascular mortality among the population with cardiometabolic multimorbidity
An erratum to this article was published (Cardiovasc Diabetol, 26 May 2025 ↗)
Authors' conclusion
This study emphasizes the prognostic significance of IR surrogates, particularly the TyG index, in predicting mortality among individuals with CMM. The TyG index constitutes a crucial element in the development of management and intervention strategies for these patients.
Study context
- Population
- Patients diagnosed with cardiometabolic multimorbidity (CMM)
- Participants
- 1,093 patients
- Exposure
- Five insulin resistance (IR) surrogates and mortality
- Outcome
- All-cause and cardiovascular mortality
- Follow-up
- Median 5.8 years
Methodological detailsmultivariable Cox proportional hazards models, restricted cubic splines
- Multivariable Cox proportional hazards models
- Restricted cubic splines
Main finding
As reported in the abstract
- All-cause deaths
- 477
- Cardiovascular deaths
- 197
- Triglyceride-glucose (TyG) index was the only surrogate significantly associated with both all-cause and CV mortality; threshold for both
- 8.85
- TyG below inflection point: CV mortality HR
- 0.483 (0.281-0.831) (95% CI)
- TyG below inflection point: all-cause mortality HR
- 0.519 (0.368-0.732) (95% CI)
- TyG above inflection point: CV mortality HR
- 1.413 (1.075-1.857) (95% CI)
- TyG above inflection point: all-cause mortality HR
- 1.279 (1.070-1.529) (95% CI)
Observational data: associations, not effects.
Further findings
Predictive value (ROC analysis)
- TyG index recognized as a dependable predictor of survival outcomes
Original publication
Association of different insulin resistance surrogates with all-cause and cardiovascular mortality among the population with cardiometabolic multimorbidity. Cardiovasc Diabetol. Published 22 January 2025. doi:10.
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