Association of C-reactive protein-triglyceride glucose index with the incidence and mortality of cardiovascular disease: a retrospective cohort study
Authors' conclusion
Our analysis revealed that elevated CTI levels were significantly associated with CVD incidence and mortality. CTI may emerge as a unique predictive marker for CVD risk.
Study context
- Population
- Adults from National Health and Nutrition Examination Survey (NHANES) 2001–2010, 2015–2018
- Participants
- 8,679 adults
- Exposure
- CTI quartiles
- Outcome
- CVD mortality, CVD incidence and all-cause mortality
Main finding
As reported in the abstract
CVD mortality, HR
2.28
1.69–3.24
All-cause mortality, HR
2.14
1.76–2.55
Observational data: associations, not effects.
Further findings
CVD incidence by CTI
- Total CVD, OR
- 2.85 (2.32-3.52) (95% CI)
- Congestive HF, OR
- 3.66 (2.46-5.35) (95% CI)
- Coronary heart disease, OR
- 2.82 (1.95-3.97) (95% CI)
- Angina pectoris, OR
- 2.85 (1.89-4.22) (95% CI)
- Heart attack, OR
- 2.59 (1.89-3.52) (95% CI)
- Stroke, OR
- 2.86 (2.00-3.85) (95% CI)
Subgroups by sex, age and glycemic status
- Association similar between male and female, and between young and elderly participants
- High CTI linked to increased CVD risk in individuals without diabetes mellitus (DM); not observed in individuals with DM
Original publication
Association of C-reactive protein-triglyceride glucose index with the incidence and mortality of cardiovascular disease: a retrospective cohort study. Cardiovasc Diabetol. Published 1 August 2025. doi:10.
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