Association of body roundness index with cardiovascular disease and all‐cause mortality among Chinese adults
Authors' conclusion
Our findings indicate a positive association between BRI and CVD and a U-shaped association between BRI and mortality. These findings underscore the importance of the BRI in assessing the risk of CVD and all-cause mortality, particularly when considering different genders and age groups.
Study context
- Population
- Chinese adults aged ≥40 years, free of cardiovascular disease (CVD) and cancer at baseline, China Cardiometabolic Disease and Cancer Cohort (4C)
- Participants
- 165,785 adults
- Exposure
- Body roundness index levels
- Outcome
- 10-year risk of CVD and all-cause mortality
- Follow-up
- Median 10.1 years
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
BRI and CVD and all-cause mortality
CVD events
10 538
Deaths
8679
Mortality nadir at body roundness index (BRI)
3.9
Observational data: associations, not effects.
Further findings
Subgroups by gender and age
- Increased CVD risk associated with higher BRI in men
- Excess risk of CVD and mortality associated with BRI diminishes with increasing age; significant harmful effect of low BRI on mortality in those aged ≥75 years
Improvement in C-statistic with BRI added to model
- CVD prediction C-statistic increase (p <0.001)
- 0.00412
- Mortality prediction C-statistic increase (p = 0.0097)
- 0.00045
Original publication
Association of body roundness index with cardiovascular disease and all‐cause mortality among Chinese adults. Diabetes Obes Metab. Published 19 February 2025. doi:10.
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