Association Between Papillary Thyroid Cancer and Primary Aldosteronism in Individuals With Hypertension
Main finding · Prevalence of PA (controls not matched by HT stage)Result — go to the resultOdds ratio 4.74 95% CI 2.26–10.55Authors' conclusion
PTC was an independent variable associated with a diagnosis of PA in HT individuals. Therefore, we propose the association between PTC and HT as a new recommendation for PA screening regardless of HT severity.
Study context
- Population
- Individuals with arterial hypertension (HT), with or without PTC
- Participants
- 137 vs 137
- Comparison
- PTC with HT vs HT controls
- PTCn = 137
- Controlsn = 137reference
- Outcome
- Prevalence of primary aldosteronism (PA)
Methodological detailspropensity score-matched, 1:1 age-, sex- and BMI-matched controls
- Propensity score-matched
- 1:1 age-, sex- and BMI-matched controls
Main finding
As reported in the abstract
Prevalence of PA (controls not matched by HT stage)
Odds ratio
4.74
95% CI 2.26–10.55
P < 0.001
By group
PTCvs Controls
OR 4.74 (95% CI 2.26–10.55); P < 0.001
Observational data: associations, not effects.
Further findings
Severe HT (stage III or resistant)
P < 0.001
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Prevalence of PA, controls matched by HT stage (secondary analysis)Multivariable analysis | 5.88 (2.79–13.37) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | PTC | Controls | P value |
|---|---|---|---|
| Prevalence of PA, controls matched by HT stage (secondary analysis)PA prevalence significantly higher with PTC | — not stated in the abstract | 9.56% (95% CI 5.39%–16.1%) | P < 0.0001 |
— not stated in the abstract
Original publication
Association Between Papillary Thyroid Cancer and Primary Aldosteronism in Individuals With Hypertension. J Clin Endocrinol Metab. Published 18 September 2024. doi:10.
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