Association between modified triglyceride glucose indices and stroke risk in middle-aged and older Chinese adults: a prospective cohort study
Authors' conclusion
In middle-aged and elderly populations, TyG-BMI, TyG-WC and TyG-WHtR are positively correlated with the risk of stroke. Maintaining favorable levels of these indices through weight and waist management may help reduce stroke risk.
Study context
- Population
- Middle-aged and older Chinese adults, China Health and Retirement Longitudinal Study (CHARLS) surveys 2011, 2013, 2015 and 2018
- Participants
- 8,677 participants
- Exposure
- Higher vs lower TyG-BMI, TyG-WC and TyG-WHtR
- Outcome
- Incident stroke
- Follow-up
- 2011 to 2018
Methodological detailsnationally representative cohort, Cox proportional hazards model, restricted cubic spline, ROC analysis, sensitivity and subgroup analyses
- Nationally representative cohort
- Cox proportional hazards model
- Restricted cubic spline
- ROC analysis
- Sensitivity and subgroup analyses
Main finding
As reported in the abstract
Stroke events
807
9.3%
TyG-BMI per 10-unit increase, HR
1.055 (1.033-1.078) (95% CI)
TyG-WC per 10-unit increase, HR
1.020 (1.012-1.027) (95% CI)
TyG-WHtR per 1-unit increase, HR
1.324 (1.178-1.487) (95% CI)
Observational data: associations, not effects.
Further findings
Stroke risk by quartile vs Q1 (adjusted HR increase, Q2/Q3/Q4)
- TyG-BMI
- 39.1%, 62.1%, 86.1%
- TyG-WC
- 40.6%, 63.0%, 88.8%
- TyG-WHtR
- 36.5%, 65.7%, 83.7%
- Reference: lowest quartile (Q1)
Dose-response (Restricted Cubic Spline (RCS))
- Nonlinear dose-response for TyG-BMI and TyG-WC; linear for TyG-WHtR
Predictive ability for stroke (AUC)
- TyG-BMI AUC
- 0.5930
- TyG-WC AUC
- 0.6078
- TyG-WHtR AUC
- 0.6032
- Comparable predictive abilities, TyG-WC slightly greater
Sensitivity and subgroup analyses
- Consistent with the main results
Original publication
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