Association between Life’s Simple 7 and life’s essential 8 with all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome population
Authors' conclusion
LS7 and LE8 demonstrate comparable predictive ability for mortality outcomes in CKM syndrome, particularly in non-advanced stages. LS7's simplicity makes it favorable for clinical and public health practice.
Study context
- Population
- Participants aged ≥20 years with cardiovascular-kidney-metabolic (CKM) syndrome, NHANES 2005–2018; non-advanced (stages 0–2) and advanced (stages 3–4) CKM stages
- Participants
- 11,487 participants
- Exposure
- High vs low CVH by LE8 and LS7 scores
- Outcome
- All-cause and cardiovascular mortality
- Follow-up
- Median 91 months
Main finding
As reported in the abstract
- High CVH
- HR (LE8, all-cause mortality) 0.63
- High CVH
- HR (LE8, cardiovascular mortality) 0.53
- High CVH
- HR (LS7, all-cause mortality) 0.69
- High CVH
- HR (LS7, cardiovascular mortality) 0.59
- All-cause deaths
- 1167
- Cardiovascular deaths
- 360
Observational data: associations, not effects.
Further findings
Mortality by CKM stage
- Similar protective associations in non-advanced CKM stages but not in advanced stages
Predictive performance (time-dependent ROC)
- LS7 and LE8 had comparable predictive ability with similar AUC values
Original publication
Association between Life’s Simple 7 and life’s essential 8 with all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome population. Diabetes Res Clin Pract. Published 21 December 2025. doi:10.
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