Association between endothelial function and skin advanced glycation end-products (AGEs) accumulation in a sample of predominantly young and healthy adults
Authors' conclusion
Higher skin AGE levels, as measured by SAF, were associated with lower FMD values, in a predominantly young, healthy population. Additionally, older age and male participants exhibited significantly lower FMD values, corresponding with compromised endothelial function. These results suggest that SAF, a simple and inexpensive marker, could be used to predict endothelial impairment before the emergence of any structural artery pathophysiology or classic cardiovascular disease risk markers.
Study context
- Population
- Adults from the general population, predominantly young and healthy (median age 28.5 y, IQR 24.4–36.0; 54% women)
- Participants
- 125 adults
- Outcome
- Relationship between endothelial function (fasting FMD) and skin AGEs accumulation measured as SAF
Main finding
As reported in the abstract
Association of FMD with SAF, age and sex
- Correlation of flow-mediated dilation (FMD) with skin autofluorescence (SAF) (ρ)
- −0.50, P < 0.001
- Correlation of FMD with chronological age (ρ)
- −0.51, P < 0.001
- Multivariable: SAF independently associated with reduced FMD, B
- −2.60 [−4.40, −0.80] (95% CI)
- Multivariable: chronological age independently associated with reduced FMD, B
- −0.10 [−0.16, −0.03] (95% CI)
- Multivariable: male sex independently associated with reduced FMD, B
- 1.40 [0.14, 2.67] (95% CI)
- Multivariable model adjusted R2
- 0.31, P < 0.001
Observational data: associations, not effects.
Original publication
Association between endothelial function and skin advanced glycation end-products (AGEs) accumulation in a sample of predominantly young and healthy adults. Cardiovasc Diabetol. Published 9 September 2024. doi:10.
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