Association between early blood glucose dynamic trajectory and mortality for critically ill patients with heart failure: Insights from real-world data
Authors' conclusion
Increasing BG trajectory within 48 h of admission is significantly associated with higher mortality in patients with HF. It is necessary to devote greater attention to the early BG dynamic changes in HF patients to optimize clinical BG management and enhance patient prognosis.
Study context
- Population
- Critically ill Heart Failure (HF) patients in the Intensive Care Unit (ICU), Medical Information Mart for Intensive Care IV database21,098 screened
- Participants
- 15,092 patients
- Exposure
- Early blood glucose (BG) trajectory subphenotypes within 48 h of ICU admission
- Increasingn = 3,503reference
- Stabilizingn = 6,250
- Decreasingn = 5,339
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailsobservational, MIMIC-IV database, BG trajectory subphenotypes by hierarchical clustering based on dynamic time-warping
- Observational
- MIMIC-IV database
- BG trajectory subphenotypes by hierarchical clustering based on dynamic time-warping
Main finding
As reported in the abstract
- Increasing subphenotype associated with the highest mortality risk at 28 days
- Stabilizing and decreasing subphenotypes: significantly lower mortality risks across all time points, HRs ranging from 0.85 to 0.88 (P<0.05 for all)
- Sensitivity analyses confirmed robustness after adjusting for various covariates
Observational data: associations, not effects.
Secondary outcomes
- Increasing subphenotype associated with the highest mortality risk at 180 days and 1 year
- Stabilizing and decreasing subphenotypes: significantly lower mortality risks across all time points (P<0.05 for all)
Original publication
Association between early blood glucose dynamic trajectory and mortality for critically ill patients with heart failure: Insights from real-world data. Diabetes Res Clin Pract. Published 16 August 2024. doi:10.
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