Assessing coronary artery stenosis exacerbated impact on left ventricular function and deformation in metabolic syndrome patients by 3.0 T cardiac magnetic resonance imaging
Authors' conclusion
Besides traditional biochemical indicators, incorporating CAS assessment and CMR assessment of the LV into routine evaluations ensures a more holistic approach to managing MetS patients. Timely intervention of CAS is crucial for improving cardiovascular outcomes in this high-risk population.
Study context
- Population
- Patients with metabolic syndrome who underwent cardiac MRI131 metabolic syndrome (MetS) + 48 controls
- Participants
- 47 / 30 / 54 / 48
- Exposure
- MetS with coronary artery stenosis (CAS)- vs NOCAS+ vs OCAS+, and controls
- MetS(CAS-)n = 47reference
- MetS(NOCAS+)n = 30
- MetS(OCAS+)n = 54
- Controln = 48
- Outcome
- Global longitudinal peak strain
Methodological detailscardiac MRI, age- and sex-matched controls
- Cardiac MRI
- Age- and sex-matched controls
Main finding
As reported in the abstract
MetS(CAS-)
- 13.02
± 2.32 · %
MetS(NOCAS+)
- 10.34
± 4.05 · %
MetS(OCAS+)
- 7.55
± 4.48 · %
P < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| LV mass indexMetS(NOCAS+) vs MetS(CAS-) · increased with NOCAS+ | P < 0.05 |
| Radial and circumferential GPS, PSSR and PDSRMetS(OCAS+) vs MetS(NOCAS+) · decreased with OCAS+ | all p < 0.05 |
Degree of CAS as independent determinant of left ventricular (LV) strain in MetS (linear regression)
- Impaired global radial peak strain (GRPS), β (p < 0.001)
- - 0.289
- Impaired global longitudinal peak strain (GLPS), β (p = 0.004)
- 0.254
Degree of CAS predicting impaired strain (ROC)
- AUC for impaired GRPS
- 0.730
- AUC for impaired GLPS
- 0.685
Original publication
Assessing coronary artery stenosis exacerbated impact on left ventricular function and deformation in metabolic syndrome patients by 3.0 T cardiac magnetic resonance imaging. Cardiovasc Diabetol. Published 18 November 2024. doi:10.
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