Are there specific clinical risk factors for the occurrence of multiple fractures? The FRISBEE study
Authors' conclusion
We found in a prospective cohort study that there were more CRFs and higher hazard ratios for the occurrence of multiple fractures than for a single fracture.
Study context
- Population
- Postmenopausal women of the FRISBEE studyfollowed 9.1 (7.2–10.6) years
- Participants
- 3,560 women
- Exposure
- Multiple incident fractures vs single incident fracture vs no incident fracture
- Multiple fracturesn = 261
- Single fracturen = 628
- No fracturen = 2,671reference
- Outcome
- Clinical risk factors specifically increasing the risk of multiple fractures
Methodological detailsCox proportional hazards models, annual collection of clinical risk factors (CRFs) and fractures
- Cox proportional hazards models
- Annual collection of CRFs and fractures
Main finding
As reported in the abstract
Risk factors for multiple fractures
- Risk factors for multiple fractures at any site: age, history of fracture, history of fall, total hip bone mineral density (BMD), spine BMD and RA
- Significant CRFs for multiple major osteoporotic fractures (MOFs): age, history of fracture, parental hip fracture, total hip BMD and RA
- More CRFs and higher HRs for multiple fractures than for a single fracture
Observational data: associations, not effects.
Further findings
Events
| Outcome | Multiple fractures | Single fracture |
|---|---|---|
| Major osteoporotic fractures (MOFs) | 146 | 435 |
- Major osteoporotic fractures (MOFs) — No MOF
- 2979
Central fractures
- Two or more central fractures
- 157
- Only one central fracture
- 389
- No central fracture
- 3014
Original publication
Are there specific clinical risk factors for the occurrence of multiple fractures? The FRISBEE study. Osteoporos Int. Published 4 January 2023. doi:10.
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