Analysis of immediate 503 thyroid carcinoma deaths: trend of single institution in 2005–2024
Authors' conclusion
ATC, including anaplastic transformation from PTC and FTC, still accounts for approximately 40% of thyroid cancer deaths after the introduction of systemic drug therapy. Respiratory insufficiency is the most common immediate cause of death.
Study context
- Population
- Deceased patients treated for thyroid carcinoma (TC) who died from TC, January 2005–June 2024
- Participants
- 503 patients
- Exposure
- 2005–2014 vs 2015–2024
- Outcome
- Frequency of ATC at diagnosis and of local-related deaths before vs after introduction of lenvatinib
Methodological detailssingle institution
- Single institution
Main finding
As reported in the abstract
ATC at diagnosis; local-related deaths
- 2005-2014 vs 2015-2024: P = 0.772
- 2005-2014 vs 2015-2024: P = 0.736
- Multivariate logistic regression adjusted for other covariates
Observational data: associations, not effects.
Further findings
Histological types
- Anaplastic TC (ATC)
- 157 (31%)
- Papillary TC (PTC)
- 253 (50%)
- Follicular TC (FTC)
- 67 (13%)
- Poorly differentiated TC
- 17 (3%)
- MTC
- 9 (2%)
Causes of death
- Respiratory insufficiency (most common)
- 192 (38%)
- Local-related death
- 98 (19%)
- Brain-related conditions
- 22 (4%)
Original publication
Analysis of immediate 503 thyroid carcinoma deaths: trend of single institution in 2005–2024. Eur Thyroid J. Published 6 March 2025. doi:10.
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