The adverse effects of metabolic disorder on left ventricular myocardial mechano-energetic efficiency and dysfunction in ischemic cardiomyopathy: insight from a cardiac magnetic resonance imaging (MRI) study
Authors' conclusion
Our results revealed whether coexisting any MetF, rather than coexisting a greater number of MetF, is associated with the reduction of LV myocardial mechano-energetic efficiency and dysfunction in patients with ICM, suggesting that clinicians should promptly identify and treat any coexisting MetF in the management of ICM patients.
Study context
- Population
- Patients with ischemic cardiomyopathy (ICM) who underwent cardiac MRI
- Participants
- 201 patients
- Exposure
- ICM patients with 0 vs 1-2 vs 3-5 coexisting metabolic risk factors
- MetF-0n = 32reference
- MetF (MetF-1)n = 92
- MetF (MetF-2)n = 77
- Outcome
- LV indexed myocardial mechano-energetic efficiency (MEEi) and LV strain
Methodological detailscardiac MRI
- Cardiac MRI
Main finding
As reported in the abstract
MetF-0
- 9.52
± 2.70 · %
MetF-1
- 7.62
± 2.73 · %
MetF-2
- 6.50
± 2.70 · %
P < 0.001
Observational data: associations, not effects.
Further findings
Multivariate association of coexisting any MetF with left ventricular (LV) mechano-energetic efficiency (MEEi) and peak strain (PS)
- MEEi, β
- - 0.093, P = 0.018
- Radial PS, β
- - 0.232, P < 0.001
- Circumferential PS, β
- 0.156, P = 0.002
- Longitudinal PS, β
- 0.192, P = 0.008
- Coexisting any MetF independently associated with decreased MEEi and PS
Multivariate association of increasing number of coexisting MetF
- Only related to reduction of circumferential PS, β
- 0.238, P = 0.006
Original publication
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