Adverse Drug Reaction-Related Hospital Admissions in Older Adults With Diabetes: Incidence and Implicated Drug Classes
Authors' conclusion
ADR-related hospital admissions were consistently more common in older adults with diabetes, compared to those without diabetes. These findings underscore the need for targeted medication safety strategies in this high-risk population.
Study context
- Population
- Individuals aged ≥65 years hospitalised 2017–2023 at the 3 major public hospitals in Tasmania, Australia
- Exposure
- Older adults with diabetes vs without diabetes
- Outcome
- Temporal trends in ADR-related hospital admissions, as estimated sex-adjusted IR
- Follow-up
- 2018 to 2022
Methodological details3 major public hospitals, National Minimum Dataset
- 3 major public hospitals
- National Minimum Dataset
Main finding
As reported in the abstract
Sex-adjusted IR of ADR-related hospital admissions
Incidence rate (IR) ratio (2018)
2.24
95% CI 2.03–2.47
Diabetes
IR ratio (2022)
2.72
95% CI 2.48–2.98; P < 0.05 for increase over period
Diabetes
Diabetes
39.9 to 40.3
per 1000 person-years
Nondiabetes
17.8 to 14.8
per 1000 person-years
Observational data: associations, not effects.
Further findings
Implicated drug classes in diabetes
- Corticosteroids, anticoagulants and antihypertensives were major contributors to adverse drug reaction (ADR)-related admissions in older adults with diabetes
Original publication
Adverse Drug Reaction-Related Hospital Admissions in Older Adults With Diabetes: Incidence and Implicated Drug Classes. Endocr Pract. Published 3 July 2025. doi:10.
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