Acute effects of GIP and GLP ‐1 receptor antagonism in totally pancreatectomized individuals: A randomized double‐blind, placebo‐controlled crossover study
Authors' conclusion
Endogenous GIP contributes to the regulation of postprandial bone resorption independently of pancreatic factors. In contrast, GIP receptor and/or GLP-1 receptor antagonism had no measurable effects on glucose metabolism, gastric emptying, appetite, food intake, triglycerides, or haemodynamics, supporting a pancreatic contribution to some of these effects of the endogenous hormones, although the surgical reconstruction may have influenced the sensitivity of the targets.
Study context
- Population
- Totally pancreatectomized individuals; basal insulin continued, morning bolus insulin omittedeach had 4 meal tests
- Participants
- 12 participants
- Comparison
- GIP receptor antagonist GIP(3-30)NH2, GLP-1 receptor antagonist exendin(9-39)NH2, their combination, vs saline (placebo) during liquid mixed meal tests
Methodological detailsdouble-blind, placebo-controlled, crossover
- Double-blind
- Placebo-controlled
- Crossover
Primary result
As reported in the abstract
Meal-induced inhibition of bone resorption (CTX), nadir as % of baseline
GIP(3-30)NH2 vs Placebo: ps <0.05 · GIP(3-30)NH2 + exendin(9-39)NH2 vs Placebo: ps <0.05
Further findings
GLP-1 plasma responses
- GLP-1 plasma responses increased during exendin(9-39)NH2 and exendin(9-39)NH2 + GIP(3-30)NH2 infusion (ps <0.05)
Other measurements
- GIP(3-30)NH2 or exendin(9-39)NH2 did not affect other measurements
Original publication
Acute effects of GIP and GLP ‐1 receptor antagonism in totally pancreatectomized individuals: A randomized double‐blind, placebo‐controlled crossover study. Diabetes Obes Metab. Published 10 October 2025. doi:10.
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