A Retrospective Cohort Analysis of Two Computerized Insulin Infusion Protocols
Authors' conclusion
The LIIP is a safe and effective CIIP in managing intravenous insulin infusion rates. Utilization of LIIP resulted in reduced time to euglycemia, P < .001, when compared with Glucommander and did not cause increased hypoglycemia during the project period. Contributing factors to the success of LIIP may include improved clinical workflow, learnability and ease of use, compatibility with the Epic electronic health record (EHR), and its unique, dynamic and adaptive algorithm.
Study context
- Population
- Patients on computerized insulin infusion protocols at six HonorHealth Hospitals, Phoenix metropolitan area
- Participants
- 778 vs 4,700
- Exposure
- Lalani Insulin Infusion Protocol vs Glucommander
- Lalani Insulin Infusion Protocol (LIIP)n = 778
- Glucommandern = 4,700reference
- Outcome
- Average time to euglycemia and average time in hyperglycemia (>180 mg/dL) and hypoglycemia (<70 mg/dL)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Subgroups: DKA/HHS, COVID-19, steroids, glomerular filtration rate (GFR) ≥60, renal insufficiency, sepsis
- Similar observations (faster time to euglycemia, similar time in hypoglycemia with LIIP) in these subgroups
Safety
Time in hypoglycemia · similar · all patients
P = 0.50
Original publication
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